Dr. Lihong Chen
Prof. Lihong Chen, doctoral supervisor, Innovation Leading Talent of the "Xingliao Talent Program" and the "100-1000-10000 Talent Project" in Liaoning Province. She obtained her Doctorate in pathophysiology from the Peking University, and was a postdoctoral fellow and assistant researcher at the University of Pennsylvania in the United States. Currently, she is a Distinguished Researcher at the Institute of Medical Sciences of Dalian Medical University. She has published academic papers in top journals such as Circulation, Science Translational Medicine, PNAS, ATVB, Atherosclerosis, and journals in the field of cardiovascular diseases. Her research was supported by the Scientist Development Grant of the American Heart Association, completed one youth project of the National Natural Science Foundation and the National Natural Science Foundation. She has won the Young Scholar Award of the International Arachidonic Acid Conference and the Outstanding Research Award of the American Heart Association. She has been a member of the editorial board of Frontiers in Pharmacology and Journal of Pharmacological Reports, and as a reviewer of several other SCI journals. She also served as a guest editor of the PPAR Research. She is a member of the Integrative Physiology Committee of the Chinese Physiological Society.
Dr. Chen’s research focuses on the role of prostaglandins and biological rhythms in chronic cardiovascular and metabolic diseases. Her group is committed to using cellular biology and molecular biology methods, combined with knockout and transgenic animal models and clinical research, to reveal the pathogenesis of chronic cardiovascular and metabolic diseases such as hypertension and translate the research results to clinical practice.
Representative publications
1. Lihong Chen，Guangrui Yang, Jiayang Zhang，Baoyin Ren，Soonyew Tang，Xuanwen Li，Garret A. FitzGerald. Time dependent hypotensive effect of aspirin in mice. Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2819-2826. doi: 10.1161/ATVBAHA.118.311296.
2. Jing Wang，Min Liu，Xiaoyan Zhang，Guangrui Yang，Lihong Chen*. Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins Other Lipid Mediat. 2018 Jan;134:1-6.
3. Guangrui Yang and Lihong Chen*. An update of microsomal prostaglandin E synthase (mPGES)-1 and PGE2 receptors in cardiovascular health and diseases. Oxid Med Cell Longev. 2016; 2016:5249086.
4. Guangrui Yang，Lihong Chen (co-first)，Gregory R. Grant Georgios Paschos，Wen-Liang Song, Erik S. Musiek，Vivian Lee，Sarah C. McLoughlin，Tilo Grosser，George Cotsarelis and Garret A. FitzGerald. Timed expression of Bmal1 influences aging and survival. Science Translational Medicine. Sci Transl Med. 2016 Feb 3;8(324):324ra16.
5. Lihong Chen，Guangrui Yang，James Monslow，Leslie Todd，David P. Cormode，Jun Tang，Gregory R. Grant，Jonathan H. DeLonge，Soon Yew Tang，John A. Lawson，Ellen Pure，and Garret A. FitzGerald. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proc Natl Acad Sci. 2014，111(18): 6828-6833
6. Lihong Chen，Guangrui Yang，Xiufeng Xu，Gregory Grant，John A. Lawson，Mohammad Bohlooly-Y and Garret A. FitzGerald. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation. 2013，127(2): 233-243.
7. Lihong Chen，Yifei Miao，Yahua Zhang，Dou Dou，Limei Liu，Xiaoyu Tian，Guangrui Yang，Dan Pu，Xiaoyan Zhang，Jihong Kang，Yuansheng Gao，Shiqiang Wang，Matthew D. Breyer，Nanping Wang，Yi Zhu，Yu Huang，Richard M. Breyer and Youfei Guan. Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor pesponse via decreasing arterial contractility. Arterioscler Thromb Vasc Biol. 2012，32(12): 3024-3032.
8. Lihong Chen，Guangrui Yang，Xiaoyan Zhang，Jing Wu，Qing Gu，Mingfen Wei，Jichun Yang，Yi Zhu，Nanping Wang and Youfei Guan. Induction of MIF expression by oxidized LDL via activation of NF-κB in vascular smooth muscle cells. Atherosclerosis. 2009, 207(2): 428-433.
ORCID：0000-0001-6370-1865