Eur Heart J 张晓燕/管又飞/陈丽红团队合作揭示前列腺素E2受体EP4调控肺动脉重构参与肺动脉高压的新机制

Sci. Transl. Med.封面亮点 | 华东师大张晓燕教授团队发现中性氨基酸转运体SLC38A2是高血压防治的重要新靶点

张晓燕&管又飞团队合作揭示核受体PXR与肾脏疾病的关系

J Cell Mol Med | Guan and Zhang’s group demonstrated that the NF-B/FXR/TonEBP pathway is involved in the protection against protects against hypertonic stress in renal medullary interstitial cells.

J Pineal Res | Chen’s group found that circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice.

Sheng Li Xue Bao | Zhang and Guan’s group reviewed the roles role of prostaglandin E(2) and its receptors in chronic liver disease.

Cell Commun Signal | Yang and Zheng’s group demonstrated that miR-574-5p can act as an endogenous ligand for human TLR8 to mediate immune and inflammatory responses and to contribute to the development of systemic lupus erythematosus and lupus nephritis.

Kidney Dis (Basel) | Zhang and Guan’s group demonstrated activation of TGR5 can promote urine concentration by upregulation of AQP2 and AQP3 expression in renal collecting ducts. TGR5 may represent an a

Adv Sci (Weinh) | Hu’s group revealed that Blautia coccoides is a newly identified bacterium increased by leucine deprivation and has a novel function in improving metabolic disorders.

Ann Rheum Dis | Ballestar’s group revealed that the disease activity in SLE drives a subversion of the epigenome and transcriptome program in monocyte differentiation, impacting the function of different subsets and allowing to generate predictive ...

JCI Insight | Wang’s group revealed that S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury.

Br J Dermatol | Wang’s groups discovered that Skp2/PTEN axis may play an important role in psoriasis-associated angiogenesis.

Trends Immunol | Ballestar’s group reviewed the Interplay between epigenetic and genetic alterations in inborn errors of immunity.

Sci China Life Sci | Zheng’s group discovered new roles of melatonin in mesothelial cell pyroptosis, peritoneal fibrosis and ultrafiltration failure.

JHEP Rep | Chen’s group demonstrated circadian control of ConA-induced acute liver injury and inflammatory response via Bmal1 regulation of Junb.